Radiolabeling of MAG3-morpholino oligomers with 188Re at high labeling efficiency and specific radioactivity for tumor pretargeting
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چکیده
منابع مشابه
Studying a specific tumor marker by a new method and analyzing its efficiency in labeling animals
Purpose: To recognize affective factors in delivering X-ray contrast agents (which have high atomic number) via gallium carrier to liver or lymphatic neoplasm cells. Materials and Methods: Since uptake of gallium by liver has been reported in numerous researches, it was bonded with a contrast media (metrizoate). X-ray imaging was done to determine geometric features of liver. Results: Rad...
متن کاملstudying a specific tumor marker by a new method and analyzing its efficiency in labeling animals
purpose: to recognize affective factors in delivering x-ray contrast agents (which have high atomic number) via gallium carrier to liver or lymphatic neoplasm cells. materials and methods: since uptake of gallium by liver has been reported in numerous researches, it was bonded with a contrast media (metrizoate). x-ray imaging was done to determine geometric features of liver. results: radio...
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Antisense promised major advances in treating a broad range of intractable diseases, but in recent years progress has been stymied by technical problems, most notably inadequate specificity, ineffective delivery into the proper subcellular compartment, and unpredictable activity within cells. Herein is an overview of the design, preparation, and properties of Morpholino oligos, a novel antisens...
متن کاملA Brief Review of Chelators for Radiolabeling Oligomers
The chemical modification of oligomers such as DNA, PNA, MORF, LNA to attach radionuclides for nuclear imaging and radiotherapy applications has become a field rich in innovation as older methods are improved and new methods are introduced. This review intends to provide a brief overview of several chelators currently in use for the labeling of oligomers with metallic radionuclides such as 99m ...
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UNLABELLED SPECT radioimmunoscintigraphy with 99mTc-labeled anti-melanoma monoclonal antibodies (MAbs) 225.28S is being used to detect uveal melanoma. Recently, pretargeting methods have been described to reduce background activity and perform imaging in a shorter time interval. METHODS We compared the three-step pretargeting method with conventional radioimmunoscintigraphy in 15 patients wit...
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ژورنال
عنوان ژورنال: Applied Radiation and Isotopes
سال: 2006
ISSN: 0969-8043
DOI: 10.1016/j.apradiso.2006.04.005